Background Image
Table of Contents Table of Contents
Previous Page  4 / 11 Next Page
Show Menu
Previous Page 4 / 11 Next Page
Page Background

What causes Peyronie’s disease?


Medical experts do not know the exact cause of

Peyronie’s disease. Many believe that Peyronie’s disease

may be the result of

acute injury to the penis

chronic, or repeated, injury to the penis

autoimmune disease—a disorder in which the body’s

immune system attacks the body’s own cells and

organs with low levels of the male hormone


Injury to the Penis

Medical experts believe that hitting or bending the penis

may injure the tissues inside. A man may injure his

penis during sex, athletic activity, or an accident. Injury

ruptures blood vessels, which leads to bleeding and

swelling inside the layers of the tunica albuginea.

Swelling inside the penis will block blood flow through

the layers of tissue inside the penis. When the blood

can’t flow normally, clots can form and trap immune

system cells. As the injury heals, the immune system

cells may release substances that lead to the formation

of too much scar tissue. The scar tissue builds up and

forms a plaque inside the penis. The plaque reduces the

elasticity of tissues and flexibility of the penis during

erection, leading to curvature. The plaque may further

harden because of calcification––the process in which

calcium builds up in body tissue.

Autoimmune Disease

Some medical experts believe that Peyronie’s disease

may be part of an autoimmune disease. Normally, the

immune system is the body’s way of protecting itself

from infection by identifying and destroying bacteria,

viruses, and other potentially harmful foreign

substances. Men who have autoimmune diseases may

develop Peyronie’s disease when the immune system

attacks cells in the penis. This can lead to inflammation

in the penis and can cause scarring.